Effects of Captopril and Propranolol on Cognitive Function and Cerebral Blood Flow in Aged Hypertensive Rats

• DOI: 10.1093/gerona/51a.6.b454
• Publication Date: 2011-06-21T14:59:33Z
• Authors: M. H. Skinner; D.-x. Tan; M. Grossmann; M. T. Pyne; R. K. Mahurin
• Keywords: Captopril

Chronic hypertension has been reported to produce adverse cognitive effects in elderly individuals, perhaps by altering central nervous system hemodynamics. The beneficial or of antihypertensive drugs on these processes are not well understood. We examined the catopril (90 mg/kg/day) and propranolol (80 function brain blood flow hypertensive normotensive rats. Cognitive was assessed Morris water maze, regional measured [14C]iodoantipyrine method. Nineteen-month-old propranolol-treated rats exhibited poorer performance (p < .05) than control had lower flows, particularly white matter regions .01). Captopril-treated did differ significantly from with regard either flow. In rats, there were no drug Thus, pressure reduction but captopril an effect