Global human tissue profiling and protein network analysis reveals distinct levels of transcriptional germline-specificity and identifies target genes for male infertility

• DOI: 10.1093/humrep/des301
• Publication Date: 2012-08-28T00:50:46Z
• Authors: Frédéric Chalmel; Aurélie Lardenois; Bertrand Evrard; Romain Mathieu; Caroline Feig; Philippe Demougin; Alexandre Gattiker; Wolfgang Schulze; Bernard Jégou; Christiane Kirchhoff; Michael Primig
• Keywords: Interactome

BACKGROUNDMammalian spermatogenesis is a process that involves complex expression program in both somatic and germ cells present the male gonad. A number of studies have attempted to define transcriptome meiosis gametogenesis rodents primates. Few human transcripts, however, been associated with testicular at different post-natal developmental stages little known about their level germline-specificity compared non-testicular tissues.