Collapse of blastocysts is strongly related to lower implantation success: a time-lapse study

• DOI: 10.1093/humrep/dev216
• Publication Date: 2015-10-14T12:26:04Z
• Authors: Julian Marcos; Sonia Pérez-Albalá; Amparo Mifsud; Marta Molla; Jose Landeras; Marcos Meseguer
• Keywords: Adult; 03 medical and health sciences; Blastocyst; 0302 clinical medicine; Reproductive Techniques, Assisted; Pregnancy; Humans; Female; Embryo Implantation; Time-Lapse Imaging; Retrospective Studies

Is there an association between blastocyst collapse patterns and implantation potential? Embryos that exhibit are as likely to hatch those do not, but less implant should not be replaced if alternatives available. Studies of in different species mammals have found most blastocysts, experience consecutive weak contractions, successfully whereas strong contractions or collapse, fail hatch. Retrospective cohort study. Seven hundred fifteen transferred blastocysts were analyzed from July 2012 May 2013. University-affiliated infertility center. Participant patients recipients oocyte donation autologous IVF cycles (n = 460). Embryo development was with a time-lapse imaging system. Variables studied included (defined the separation ≥50% surface trophectoderm zona pellucida), kinetic variables, embryo morphology, clinical pregnancy rates. A total 139 presented (19.4%), these 8 2 collapses 3 collapses. The timings cleavages time taken reach morula stage blastulation significantly shorter embryos than without. Implantation rates compared where either all none replaced, implanted so data known for every embryo. Among 408 without 94 at least one (94) 48.5% (95% confidence intervals (CI) 46.7–53.4%) 35% CI 25.3–44.9%), respectively. percentage hatched similar both groups 28.7 31%, retrospective nature study limits its potential value. Study pattern blastocyst, may assist selection increase IVF/ICSI success this work supported by Spanish Ministry Economy Competitiveness (PI14/00523) through Instituto de Salud Carlos III program. None authors any economic affiliation Vitrolife nor other conflicts interest. Not applicable.