Gastrointestinal hormone secretion in women with polycystic ovary syndrome: an observational study

• DOI: 10.1093/humrep/dev231
• Publication Date: 2015-09-16T00:39:45Z
• Authors: Tzuchun Lin; Shengxian Li; Hua Xu; Huan Zhou; Rilu Feng; Wei Liu; Yun Sun; Jing Ma
• Keywords: Peptide YY

Is the secretion of gastrointestinal hormones impaired in patients with polycystic ovary syndrome (PCOS)? Gastrointestinal hormone levels were abnormal PCOS. The glucagon-like peptide-1 (GLP-1) and peptide tyrosine–tyrosine (PYY) are both involved signaling satiety. Secretion GLP-1 PYY response to nutrients small intestine plays an important role energy metabolism. Most PCOS overweight or obese, which suggests dysregulation appetite. In order evaluate PCOS, a cohort study was undertaken, involving 30 29 BMI-matched healthy women recruited from Shanghai Renji Hospital between 1 March 2013 May 2014. After overnight fast, all participants underwent oral glucose tolerance test. Blood sampled frequently for measurement blood plasma insulin, total concentrations. Fasting postprandial insulin significantly higher compared controls (P < 0.05). (t = 0 min; mean ± SEM) also group (17.5 1.07 pM versus 14.1 1.16 pM, P 0.05; 29.7 2.39 22.8 2.09 However, there no differences either fasting postprandially. lower obese than lean number subjects examined responses rather physiological meal. Deficient does not contribute excessive food intake pathophysiology This work supported by grants Jiaotong University, School Medicine, Science Technology Fund (Grant No. 12XJ10015), Commission Municipality 14441903502) Municipal Health Bureau 20124273). All authors declare that is conflict interest could be perceived as prejudicing impartiality research reported.