Does age of the sperm donor influence live birth outcome in assisted reproduction?

• DOI: 10.1093/humrep/dev331
• Publication Date: 2016-01-14T01:07:42Z
• Authors: N.K. Ghuman; E. Mair; K. Pearce; M. Choudhary
• Keywords: Live birth

Does age of the sperm donor have an effect on reproductive outcomes (live birth rate and miscarriage occurrence) insemination or in vitro fertilization treatment using donated sperm?Live occurrence assisted reproduction sperms was not found to be affected by donors up 45 years old.Literature outcome medically is scarce. Most researchers agree that semen parameters deteriorate with increasing paternal age. However, there no substantial evidence suggest this deterioration adversely affects couples undergoing reproduction.This retrospective cohort study analysed 46 078 first treatments fresh (IVF)/intracytoplasmic injection (ICSI) cycles from 1991 2012.The IVF/ICSI (46 cycles) long-term anonymized data registry 2012 HFEA, UK regulator, were binary logistic modelling technique for association between occurrence). The statistical package SPSS (version 21) used analysis results considered statistically significant if P-value <0.05.Of women, 84.6% (N = 38 974) underwent remainder, 15.4% 7104), had sperm. live decreased female both groups; In group, it 11.1% 18-34 year old 8.3% 35-37 women 4.7% 38-50 women. corresponding figures group 28.9, 22.0 12.9% respectively. each these subgroups, declining likelihood (P > 0.05). (i.e. number miscarriages per 100 commencing treatment) 1.3% 1.9% treatment. donation 5.7, 8.4 6.8% suggestive any unfavourable advancing odds 0.05).As are a select population based good indices, generalization at large may possible. Although subgroups controlled age, modality previous cycles, adjustments certain potential compounding factors, such as smoking status, BMI stimulation protocol possible.Live following weren't years. view demand sperm, further studies required ascertain safe upper limit donors.No funding received individual agency. NG Commonwealth Scholarship duration study. authors do conflicts interest declare.