Genetic Background Amplifies the Effect of Immunodeficiency in Antibiotic Efficacy Against Borrelia burgdorferi

• DOI: 10.1093/infdis/jiaa719
• Publication Date: 2020-11-13T20:10:40Z
• Authors: Bijaya Sharma; Julie E McCarthy; Cecily A Freliech; Morgen M Clark; Linden T Hu
• Keywords: 0301 basic medicine; Lyme Disease; Mice, Inbred C3H; Immunologic Deficiency Syndromes; Anti-Bacterial Agents; 3. Good health; Mice, Inbred C57BL; Mice; 03 medical and health sciences; Borrelia burgdorferi; Doxycycline; Animals; Genetic Background

Abstract Unrecognized immunodeficiency has been proposed as a possible cause of failure antibiotics to resolve symptoms Lyme disease. Here, we examined the efficacy doxycycline in different immunodeficient mice identify defects that impair antibiotic treatment outcomes. We found had significantly lower absence adaptive immunity, specifically B cells. This effect was most pronounced C3H compared with C57BL/6 mice, suggesting role for genetic background beyond immunodeficiency. Addition single dose ceftriaxone effectively cleared infection severe combined