Very Early Initiation of Antiretroviral Therapy During Acute HIV Infection Is Associated With Normalized Levels of Immune Activation Markers in Cerebrospinal Fluid but Not in Plasma

• DOI: 10.1093/infdis/jiz030
• Publication Date: 2019-01-15T15:09:46Z
• Authors: Joanna Hellmuth; Bonnie M Slike; Carlo Sacdalan; John Best; Eugene Kroon; Nittaya Phanuphak; James L K Fletcher; Peeriya Prueksakaew; Linda L Jagodzinski; Victor Valcour; Merlin Robb; Jintanat Ananwora...; Isabel E Allen; Shelly J Krebs; Serena Spudich
• Keywords: Neopterin; Raltegravir; Regimen

Chronic immune activation in the blood and central nervous system is a consequence of human immunodeficiency virus (HIV) infection that contributes to disease morbidity can occur despite virally suppressive antiretroviral therapy (ART). The trajectory HIV-related inflammation may vary with timing ART initiation. We examined markers cerebrospinal fluid (CSF) specimens collected over 96 weeks from participants who initiated during acute HIV (AHI).