Pharmacodynamics of cefepime in patients with Gram-negative infections

Male 0303 health sciences Microbial Sensitivity Tests Middle Aged United States Anti-Bacterial Agents Cephalosporins 3. Good health Hospitals, University 03 medical and health sciences Hospitals, Urban Treatment Outcome Gram-Negative Bacteria Humans Regression Analysis Female Prospective Studies Cefepime Gram-Negative Bacterial Infections
DOI: 10.1093/jac/dkf130 Publication Date: 2002-08-30T20:38:44Z
ABSTRACT
We conducted a prospective, open-label study to delineate a relationship between exposure and outcomes in 36 patients treated with cefepime. Twenty patients had documented Gram-negative infections. Timed blood and urine samples were obtained at steady state to determine pharmacokinetic and pharmacodynamic parameters. Microbiological success was significantly correlated with the proportion of the dosing interval that cefepime concentrations exceeded 4.3 x MIC. Our results support in vitro data that suggest bactericidal activity of beta-lactams is optimized at concentrations approximately 4 x MIC. These results should be validated by large prospective clinical trials.
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