Pharmacodynamics of cefepime in patients with Gram-negative infections

• DOI: 10.1093/jac/dkf130
• Publication Date: 2002-08-30T20:38:44Z
• Authors: V. H. Tam
• Keywords: Cefepime; Pharmacodynamics

We conducted a prospective, open-label study to delineate relationship between exposure and outcomes in 36 patients treated with cefepime. Twenty had documented Gram-negative infections. Timed blood urine samples were obtained at steady state determine pharmacokinetic pharmacodynamic parameters. Microbiological success was significantly correlated the proportion of dosing interval that cefepime concentrations exceeded 4.3 × MIC. Our results support vitro data suggest bactericidal activity β-lactams is optimized ∼4 These should be validated by large prospective clinical trials.