Pharmacodynamics of cefepime in patients with Gram-negative infections
Male
0303 health sciences
Microbial Sensitivity Tests
Middle Aged
United States
Anti-Bacterial Agents
Cephalosporins
3. Good health
Hospitals, University
03 medical and health sciences
Hospitals, Urban
Treatment Outcome
Gram-Negative Bacteria
Humans
Regression Analysis
Female
Prospective Studies
Cefepime
Gram-Negative Bacterial Infections
DOI:
10.1093/jac/dkf130
Publication Date:
2002-08-30T20:38:44Z
AUTHORS (1)
ABSTRACT
We conducted a prospective, open-label study to delineate a relationship between exposure and outcomes in 36 patients treated with cefepime. Twenty patients had documented Gram-negative infections. Timed blood and urine samples were obtained at steady state to determine pharmacokinetic and pharmacodynamic parameters. Microbiological success was significantly correlated with the proportion of the dosing interval that cefepime concentrations exceeded 4.3 x MIC. Our results support in vitro data that suggest bactericidal activity of beta-lactams is optimized at concentrations approximately 4 x MIC. These results should be validated by large prospective clinical trials.
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