Efficacy of nitazoxanide, tizoxanide and tizoxanide/albendazole sulphoxide combination against Taenia crassiceps cysts

• DOI: 10.1093/jac/dkl463
• Publication Date: 2006-11-17T20:25:33Z
• Authors: F. Palomares-Alonso; J. C. Piliado; G. Palencia; A. Ortiz-Plata; H. Jung-Cook
• Keywords: Albendazole; Taenia crassiceps; Nitazoxanide; Neurocysticercosis

Neurocysticercosis is a common parasitic disease in the CNS humans caused by metacestode Taenia solium, with high incidence developing countries. Albendazole drug of choice. However, wide interindividual variability response has been reported. In order to evaluate alternative treatment options, vitro efficacy nitazoxanide, its main metabolite tizoxanide as well and albendazole sulphoxide combination was tested against crassiceps cysts.T. cysts were incubated culture medium containing different concentrations (0.037-0.42 microg/mL). The effect evaluated fixed-concentration ratio (1:1). Isobolographic analyses used define kind interaction between drugs. Morphological ultrastructural alterations over parasite tissue observed light transmission electron microscopy.Nitazoxanide exhibited cestocidal activity which time-concentration-dependent. EC(50) values 0.15, 0.12 0.080 microg/mL for sulphoxide, respectively. No statistical differences found, indicating that nitazoxanide are equally potent sulphoxide. faster than each alone. analysis showed additive. Nitazoxanide had an on germinal layer, where lipid droplets found. produced less damage layer. After combination, accumulation within layer found.Our results suggest could be useful cysticercosis infections. Additional vivo studies required confirm this hypothesis.