Continued propagation of the CRF19_cpx variant among HIV-positive MSM patients in Spain

• DOI: 10.1093/jac/dkx474
• Publication Date: 2017-11-20T23:12:29Z
• Authors: S Pérez-Parra; M Álvarez; J A Fernandez-Cab...; A B Pérez; J Santos; O Bisbal; A Aguilera; M Rivero; L García-Fraile; F García
• Keywords: Molecular Epidemiology

The HIV-1 CRF19_cpx genetic form has been recently associated with greater pathogenicity. We used CoRIS, a national cohort of 31 reference hospitals in Spain, to investigate the current epidemiological situation this variant Spain.We analysed 4734 naive HIV-1-positive patients diagnosed during 2007-15 period an available pol gene sequence CoRIS resistance database. was ascribed through REGA3.0 and confirmed by phylogenetic analysis. presence transmission clusters maximum likelihood [with randomized accelerated (RAxML) program] time most recent common ancestor using Bayesian inference (BEAST, v. 1.7.5).Nineteen were infected CRF19_cpx: all male, they had mean age 42.9 years (95% CI: 36.4-52.5 years), majority MSM [n = 18 (95%)] Spanish nationality 16 (84.2%)] high CD4+ T cell counts (∼415 cells/mm3). Fifteen grouped into four different clusters: two (two each) from Valencia another cluster one patient Madrid Seville. found larger that nine southern Spain (Malaga Seville), which six presented mutation G190A. estimated origin take place between 2009 2010.We demonstrate spread among young HIV-positive we note expansion who carry alert healthcare managers enhance preventive measures prevent continuous CRF19_cpx.