Improving phage therapy by evasion of phage resistance mechanisms

• DOI: 10.1093/jacamr/dlae017
• Publication Date: 2024-02-09T12:59:54Z
• Authors: Inés Bleriot; Olga Pacios; Lucia Blasco; Laura Fernández-G...; María López; Concha Ortiz-Cart...; Antonio Barrio-Pu...; Rodolfo García-Co...; Jean-Paul Pirnay; Thomas K Wood; María Tomás
• Keywords: Phage therapy; Prophage; Evasion (ethics); Multidrug tolerance

Abstract Antibiotic failure is one of the most worrisome threats to global health. Among new therapeutic efforts that are being explored, use bacteriophages (viruses kill bacteria), also known as ‘phages’, extensively studied a strategy target bacterial pathogens. However, main drawbacks phage therapy plethora defence mechanisms bacteria defend themselves against phages. This review aims summarize approaches evaluated overcome systems, including innovative applied: circumvention receptor mutations; modification prophages; targeting CRISPR-Cas systems and biofilm matrix; engineering safer more efficacious phages; inhibition anti-persister strategies used by bacteria.