Dietary cysteamine hydrochloride protects against oxidation, inflammation, and mucosal barrier disruption of broiler chickens challenged with Clostridium perfringens

• DOI: 10.1093/jas/sky292
• Publication Date: 2018-09-29T09:35:13Z
• Authors: Ning Liu; Lin Lin; Jinquan Wang; Feike Zhang; Jian-ping Wang
• Keywords: Clostridium perfringens; Occludin; Cysteamine; Intestinal Permeability; Jejunum

This study aimed to investigate the effect of dietary cysteamine hydrochloride (CSH) on growth performance, oxidation, inflammation, and gene expression cytoskeleton tight junction in intestinal mucosa broiler chickens challenged with Clostridium perfringens (C. perfringens). A total 360 one-day-old chicks were randomly distributed into 5 groups for a negative control (NC, without C. challenge), positive (PC, PC plus CSH at 100, 150, or 200 mg/kg diet. The results showed that average daily gain, gain:feed, cecal population enterotoxin negatively affected (P < 0.05) by challenge, but conversely supplementation, G:F reached level NC group. group increased serum diamine oxidase, malondialdehyde, protein carbonyl, interleukin-6, interleukin-1β, tumor necrosis factor-α, whereas supplementation decreased these parameters. Moreover, challenge worsened disruption mucosal downregulating mRNA levels actin muscle Z-line alpha, syncoilin, synemin, tubulin, claudin-1, zona occludens protein-2, while parameters partially compensated supplementation. For dose trends CSH, there linear quadratic effects enterotoxins, tubulin alpha 1c, synemin. In conclusion, can be an alternative against infection beneficially regulating gut pathogenic bacteria cytoskeleton, chickens.