What is the Hippo pathway? Is the Hippo pathway conserved in Caenorhabditis elegans?

• DOI: 10.1093/jb/mvt060
• Publication Date: 2013-07-11T01:43:24Z
• Authors: Z. Yang; Y. Hata
• Keywords: Hippo signaling pathway

The Hippo pathway was originally identified in Drosophila as the signalling that governs organ size. core of harbours two protein kinases (Hippo and Warts). phosphorylates activates Warts, which turn inactivates transcriptional co-activator Yorkie. As Yorkie mediates cell cycle-promoting anti-apoptotic gene transcriptions, suppresses cycle progression induces apoptosis. named after Hippo, regarded a key component. initially considered to be well conserved mammals. Indeed mammalian homologues Warts negatively regulate homologue function tumour suppressors. However, researchers have numerous additional components both mammals significant interspecies diversity is now evident. To make things more complicated, regulation does not necessarily depend on homologues. In this commentary, we reconsider what essential for try sort out controversial arguments discussion evolutionary root pathway.