Diffusion kurtosis imaging and tumour microstructure for monitoring response to radiotherapy in human nasopharyngeal carcinoma xenografts

• DOI: 10.1093/jjco/hyaa002
• Publication Date: 2020-01-02T20:09:00Z
• Authors: Xiang Zheng; Yunbin Chen; Dechun Zheng; Youping Xiao; Jiayou Chen; Jianji Pan; Weibo Chen
• Keywords: Kurtosis

Abstract Objective To investigate the correlations and feasibility of diffusion kurtosis imaging (DKI) parameters tumour histopathology after radiotherapy in human nasopharyngeal carcinoma (NPC) xenografts on nude mice. Materials Methods Seventy-two mice were used for construction CNE-1 (radio-insensitive) CNE-2 (radio-sensitive) NPC xenograft models, followed by fraction irradiation at different doses X-ray. The randomly divided into six groups each cell line models according to dose X-ray they have received with group. DKI scan was performed radiation. parameters, AQP-1 biomarkers detected. One-way ANOVA Pearson’s correlation analysis statistical analysis. Results In xenografts, D values increased (P < 0.01 P 0.001), while K 0.001) size 0.001 reduced during irradiation. Additionally, density (CD) expressions decreased, necrosis ratio (NR) 0.001). changes negatively correlated (r = −0.856, CD −0.918, mRNA protein −0.381, 0.022) positively NR 0.908, xenografts. 0.964, 0.888, 0.955, 0.330, 0.049) expression levels −0.930, However, there no between AQP-1. Conclusion Changes fractional are closely related cellular pathological characteristics, especially reduction induction. These exhibit potential abilities monitoring response radio-sensitive