The mitochondrial fission protein DRP1 influences memory CD8+ T cell formation and function

• DOI: 10.1093/jleuko/qiad155
• Publication Date: 2023-12-07T05:44:24Z
• Authors: Marissa G Stevens; Frank M Mason; Timothy N J Bullock
• Keywords: Dynamins; Memory T Cells; CD8-Positive T-Lymphocytes; Mitochondrial Dynamics; Mitochondria

Abstract Pharmacological methods for promoting mitochondrial elongation suggest that effector T cells can be altered to support a memory cell–like metabolic state. Such approaches may enhance the development of immunological memory. Therefore, we hypothesized deletion fission protein dynamin-related 1 (DRP1) would lead and generate large cell population, an approach could exploited vaccination protocols. We find that, as expected, while DRP1 from in dLckCre × Drp1flfl does compromise magnitude functionality primary CD8+ cells, disproportionately pool form. In contrast DRP1-deficient mount secondary response comparable control with respect kinetics, magnitude, capabilities. Interestingly, relative propensity form absence was associated neither differentiation toward more precursor nor decreased cellular death cells. Instead, tendency is receptor expression. Remarkably, competitive environment DRP1-replete compromised generation primary, memory, responses, indicating targeting need carefully tailored.