Neutrophil phenotype, effector functions, and microbicidal activity in patients with SARS-CoV-2-associated ARDS

• DOI: 10.1093/jleuko/qiae195
• Publication Date: 2024-09-13T19:29:46Z
• Authors: Quentin Quelven; Murielle Grégoire; Valentin Coirier; Arnaud Gacouin; Simon Le Gallou; Vincent Cattoir; Michel Cogné; Hélène Guegan; Jean-Pierre Gangneux; Mikael Roussel; Karin Tarte; Jean-Marc Tadié; Mathieu Lesouhaitier
• Keywords: Pandemic

Abstract Critically ill patients admitted to the intensive care unit (ICU) for SARS-CoV-2-induced acute respiratory distress syndrome (ARDS) are at increased risk of bacterial and fungal secondary pulmonary infections due acquired immune dysfunction. Given that activity neutrophils has not been described in these patients, we aimed investigate function ICU admission on day 7 (D7) postadmission. Neutrophil maturation several functional indicators were investigated. We detected a significant decrease reactive oxygen species production D7, but did observe any other alterations neutrophil function. Furthermore, bronchoalveolar lavage obtained from displayed no inhibitory effect healthy donors. These findings indicate ARDS do acquire dysfunction within first week their stay, which suggests nosocomial among dysfunctions.