Sugar-Sweetened Beverage Consumption and Plasma Lipoprotein Cholesterol, Apolipoprotein, and Lipoprotein Particle Size Concentrations in US Adults

• DOI: 10.1093/jn/nxac166
• Publication Date: 2022-08-03T02:54:52Z
• Authors: Danielle E Haslam; Daniel I Chasman; Gina M Peloso; Mark A Herman; Josée Dupuis; Alice H Lichtenstein; Caren E Smith; Paul M Ridker; Paul F Jacques; Samia Mora; Nicola M McKeown
• Keywords: Lipoprotein particle; Dyslipidemia

Prospective cohort studies have found a relation between sugar-sweetened beverage consumption (SSB; sodas and fruit drinks) dyslipidemia. There is limited evidence linking SSB to emerging features of dyslipidemia, which can be characterized by variation in lipoprotein particle size, remnant-like (RLP), apolipoprotein concentrations.To examine the association plasma cholesterol, apolipoprotein, size concentrations among US adults.We examined participants from Framingham Offspring Study (FOS) (1987-1995; n = 3047) Women's Health (1992; 26,218). Plasma LDL-C, (apo) B, HDL-C, apoA1, triglyceride (TG), non-HDL-C, total: HDL-cholesterol ratio, apoB: apoA1 were quantified both cohorts, apoE, apoC3, RLP-TG, RLP-cholesterol FOS only. Lipoprotein sizes calculated NMR signals for subclass (triglyceride-rich particles [TRL-P; very large, medium, small, small], LDL-particles [LDL-P; HDL-particles [HDL-P; small]). was estimated food frequency questionnaire data. We associations all apoprotein measures linear regression models, adjusting confounding factors, such as lifestyle, diet, traditional risk factors.SSB positively associated with apoB, TG, RLP-C, non-HDL-C HDL cholesterol negatively HDL-C (P-trend ranges < 0.0001 0.003). After adjustment consumers had smaller LDL-P HDL-P sizes, lower large medium HDL-P, higher small LDL-P, TRL-P 0.0009).Higher multiple dyslipidemia that been linked cardiometabolic adults.