Development of a comprehensive method based on quantitative 1H NMR for quality evaluation of Traditional Chinese Medicine injection: a case study of Danshen Injection

• DOI: 10.1093/jpp/rgac034
• Publication Date: 2022-04-26T13:21:42Z
• Authors: Wenzhu Li; Fang Zhao; Jiayu Yang; Jianyang Pan; Haibin Qu
• Keywords: Proton Magnetic Resonance Spectroscopy; Salvia miltiorrhiza; Medicine, Chinese Traditional; Drugs, Chinese Herbal; Injections; 3. Good health

This study aimed to establish a rapid and comprehensive method for quantitative determination of complex ingredients in Traditional Chinese Medicine injections.A 1H nuclear magnetic resonance was developed simultaneously quantify chemical components Danshen Injection. Multivariate statistical analysis technique applied quality evaluation multiple batches injection.A complete signal attribution the spectrum injection performed first time. A total 32 were identified from Among them, 20 quantified simultaneously, accounting up 80% (w/w) solids 95% organic matter, representing success compared previous studies. The further analyze 13 Injection three manufacturers make realistic analysis.It found that information provides an adequate characterization profiles among different commercial offered guarantee improving consistency safety injections.