Decreased Serum Levels of Ghrelin and Brain-Derived Neurotrophic Factor in Premenopausal Women With Metabolic Syndrome

• DOI: 10.1093/labmed/lmx087
• Publication Date: 2017-11-09T15:44:04Z
• Authors: Masoumeh Jabbari; Sorayya Kheirouri; Mohammad Alizadeh
• Keywords: Adult; Metabolic Syndrome; 0301 basic medicine; Brain-Derived Neurotrophic Factor; Middle Aged; 16. Peace & justice; Ghrelin; 3. Good health; 03 medical and health sciences; Premenopause; Case-Control Studies; Humans; Female

We aimed to investigate the association between serum levels of ghrelin and brain-derived neurotrophic factor (BDNF) with MetS its components in premenopausal women.43 patients 43 healthy controls participated this study. Participants' body mass index (BMI), waist circumference (WC), systolic diastolic blood pressure (SBP DBP) were measured. Serum total cholesterol (TC), triglyceride (TG), low high density lipoprotein (LDL-C HDL-C), fasting sugar (FBS), insulin, BDNF determined. Homeostasis model assessment insulin resistance (HOMA-IR) was also calculated.Participants group had higher waist-to-hip ratios, elevated SBP DBP, TG, FBS when compared control group. significantly lower participants than healthier subjects. There a strong, positive correlation levels. Both proteins negatively correlated FBS, HOMA-IR positively HDL-C. Furthermore, associated levels.The findings indicate that variations occur circulating level patients. A strong suggests production, release or practice these 2 might be related mechanically.