Disuniting Uniformity: A Pied Cladistic Canvas of mtDNA Haplogroup H in Eurasia

• DOI: 10.1093/molbev/msh209
• Publication Date: 2004-07-15T00:29:47Z
• Authors: Eva-Liis Loogväli; Urmas Roostalu; Boris A. Malyarchuk; Miroslava V. Derenko; Toomas Kivisild; Ene Metspalu; Kristiina Tambets; Maere Reidla; Helle-Viivi Tolk; Jüri Parik; Erwan Pennarun; Sirle Laos; Arina Lunkina; Maria Golubenko; Lovorka Barać; Marijana Peričić; Oleg P. Balanovsky; Vladislava Gusar; Elsa K. Khusnutdi...; Vadim Stepanov; Valery Puzyrev; Pavao Rudan; Elena V. Balanovska; Elena Grechanina; Christelle Richard; Jean-Paul Moisan; André Chaventré; Nicholas P. Anagnou; Kalliopi I. Pappa; Emmanuel N. Micha...; Mireille Claustres; Mukaddes Gölge; Ilia Mikerezi; Esien Usanga; Richard Villems
• Keywords: Haplogroup; Monophyly; Hypervariable region

It has been often stated that the overall pattern of human maternal lineages in Europe is largely uniform. Yet this uniformity may also result from an insufficient depth and width phylogenetic analysis, particular predominant western Eurasian haplogroup (Hg) H comprises nearly a half European mitochondrial DNA (mtDNA) pool. Making use coding sequence information 267 mtDNA Hg sequences, we have analyzed 830 genomes, 11 European, Near Middle Eastern, Central Asian, Altaian populations. In addition to seven previously specified subhaplogroups, define fifteen novel subclades present extant populations Eurasia. The refinement resolution allowed us resolve large number homoplasies trees based on first hypervariable segment (HVS-I) mtDNA. As many as 50 out 125 polymorphic positions HVS-I were found be mutated more than one subcluster H. phylogeographic analysis revealed sub-Hgs H1*, H1b, H1f, H2a, H3, H6a, H6b, H8 demonstrate distinct patterns. monophyletic subhaplogroups provide means for further progress understanding (pre)historic movements women Eurasia present-day genetic diversity Eurasians general.