Chromosome 11q13.3 variant modifies renal cell cancer risk in a Chinese population

• DOI: 10.1093/mutage/ger085
• Publication Date: 2011-12-01T05:43:34Z
• Authors: Q. Cao; C. Qin; X. Ju; X. Meng; M. Wang; J. Zhu; P. Li; J. Chen; Z. Zhang; C. Yin
• Keywords: Male; Transcription, Genetic; Chromosomes, Human, Pair 11; Sequence Analysis, DNA; Middle Aged; Scavenger Receptors, Class B; Polymorphism, Single Nucleotide; Kidney Neoplasms; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Asian People; Risk Factors; Case-Control Studies; Proto-Oncogene Proteins; Basic Helix-Loop-Helix Transcription Factors; Humans; Cyclin D1; Female; Genetic Predisposition to Disease; Carcinoma, Renal Cell; Genetic Association Studies

A recent genome-wide association study of renal cell carcinoma (RCC) in European population has identified genetic variants the regions 2p21 (rs7579899), 11q13.3 (rs7105934) and 12q24.31 (rs4765623) conferred susceptibility to RCC. In our study, we assessed whether these polymorphisms are also associated with RCC risk a Chinese population. We genotyped using TaqMan method their associations case–control 710 patients histologically confirmed 760 cancer-free controls. Normal tissues adjacent tumors were used evaluate functional consequences polymorphisms. found that rs7105934 was significantly reduced [adjusted odds ratio (OR) = 0.67, 95% confidence intervals (CIs) 0.47–0.95, GA+AA versus GG], particularly among subgroups normal-weight individuals (OR 0.51, 95%CI 0.29–0.88), never-smokers 0.53, 0.33–0.85) non-drinkers 0.57, 0.370.87). Furthermore, GA genotype lower levels CCND1 mRNA compared GG genotype, although this only marginally significant (P 0.055). No between rs7579899 or observed. Our results suggest on may confer Large population-based prospective studies required validate loci risk.