Cardiovascular disease biomarkers derived from circulating cell-free DNA methylation

• DOI: 10.1093/nargab/lqad061
• Publication Date: 2023-06-28T13:15:04Z
• Authors: Rafael R C Cuadrat; Adelheid Kratzer; Hector Giral Arnal; Anja C Rathgeber; Katarzyna Wreczycka; Alexander Blume; Irem B Gündüz; Veronika Ebenal; Tiina Mauno; Brendan Osberg; Minoo Moobed; Johannes Hartung; Kai Jakobs; Claudio Seppelt; Denitsa Meteva; Arash Haghikia; David M Leistner; Ulf Landmesser; Altuna Akalin
• Keywords: Unstable angina

Abstract Acute coronary syndrome (ACS) remains a major cause of worldwide mortality. The occurs when blood flow to the heart muscle is decreased or blocked, causing tissues die malfunction. There are three main types ACS: Non-ST-elevation myocardial infarction, ST-elevation and unstable angina. treatment depends on type ACS, this decided by combination clinical findings, such as electrocardiogram plasma biomarkers. Circulating cell-free DNA (ccfDNA) proposed an additional marker for ACS since damaged can release bloodstream. We used ccfDNA methylation profiles differentiating between provided computational tools repeat similar analysis other diseases. leveraged cell specificity deconvolute origin find methylation-based biomarkers that stratify patients. identified hundreds markers associated with validated them in independent cohort. Many were genes involved cardiovascular conditions inflammation. showed promise non-invasive diagnostic acute events. These methods not limited events, may be chronic diseases well.