Association between preoperative neurocognitive status and IDH1 mutation status in high-grade gliomas

• DOI: 10.1093/nop/npac077
• Publication Date: 2022-09-30T19:52:01Z
• Authors: Evangelia Liouta; Aristotelis V Kal...; Spyridon Komaitis; Evangelos Drosos; Christos Koutsarn...; Juan M García-Gómez; Javier Juan-Albar...; Vasileios Katsaros; Theodosis Kalamat...; Theodoros Argyrakos; George Stranjalis
• Keywords: Neurocognitive; Association (psychology)

High-grade glioma (HGG) patients present with variable impairment in neurocognitive function (NCF). Based on that, isocitrate dehydrogenase 1 (IDH1) wild-type HGGs are more aggressive than IDH1 mutant-type ones, we hypothesized that HGG would exhibit severe NCF deficits their mutant counterparts.NCF was assessed by Mini Mental Status Exam (MMSE), Trail Making Test (TMT), Digit Span (DS), and Controlled Word Association (COWAT) tests 147 preoperatively.Analyses between groups revealed a significant difference MMSE concentration component (p ≤ .01), DS TMTB COWAT .01) scores, the wild group performing worse one. Age tumor volume were inversely correlated (r = -4.78, p < -.401, -.328, phonemic scores -.599, respectively, but only for group. Analyses age-matched subsamples of no age effect NCF. Tumor grade showed nonsignificance > .05) 2 mutation subgroups IV patients. On contrary, III backwards subgroups, one outperforming one.Our findings indicate greater impairment, executive functions particularly, compared to suggesting growth kinetics may play profound role other demographic parameters clinical