Impaired health-related quality of life in idiopathic inflammatory myopathies: a cross-sectional analysis from the COVAD-2 e-survey

• DOI: 10.1093/rap/rkae028
• Publication Date: 2024-02-29T21:54:30Z
• Authors: Akira Yoshida; Yuan Li; Vahed Maroufy; Masataka Kuwana; Syahrul Sazliyana...; Ashima Makol; Parikshit Sen; James B Lilleker; Vishwesh Agarwal; Esha Kadam; Phonpen Akawatcha...; Jessica Day; Marcin Milchert; Yi-Ming Chen; Dzifa Dey; Tsvetelina Velikova; Sreoshy Saha; Abraham Edgar Gra...; Ioannis Parodis; Elena Nikiphorou; Ai Lyn Tan; Arvind Nune; Lorenzo Cavagna; Carlos Enrique To...; Carlo Vinicio Cab...; Miguel A Saavedra; Samuel Katsuyuki ...; Nelly Ziade; Lina El Kibbi; Johannes Knitza; Oliver Distler; Hector Chinoy; Vikas Agarwal; Rohit Aggarwal; Latika Gupta; ; Zoltán Griger; Sinan Kardes; Melinda Nagy Vince; Yogesh Preet Singh; Rajiv Ranjan; Avinash Jain; Sapan C Pandya; Rakesh Kumar Pilania; Aman Sharma; M Manesh Manoj; Vikas Gupta; Chengappa G Kavad...; Pradeepta Sekhar ...; Sajal Ajmani; Sanat Phatak; Rudra Prosad Goswami; Abhra Chandra Cho...; Ashish Jacob Mathew; Padnamabha Shenoy; Ajay Asranna; Keerthi Talari Bo...; Anuj Shukla; Arunkumar R Pande; Kunal Chandwar; Akanksha Ghodke; Hiya Boro; Zoha Zahid Fazal; Binit Vaidya; Döndü Üsküdar Cansu; Reşit Yıldırım; Armen Yuri Gasparyan; Nicoletta Del Papa; Gianluca Sambataro; Atzeni Fabiola; Marcello Govoni; Simone Parisi; Elena Bartoloni B...; Gian Domenico Seb...; Enrico Fusaro; Marco Sebastiani; Luca Quartuccio; Franco Franceschini; Pier Paolo Sainaghi; Giovanni Orsolini; Rossella De Angelis; Maria Giovanna Da...; Vincenzo Venerito; Silvia Grignaschi; Alessandro Giollo; Alessia Alunno; Florenzo Iannone; Marco Fornaro; Lisa S Traboco; Suryo Anggoro Kus...; Jesús Loarce-Martos; Sergio Prieto-Gon...; Raquel Aranega Go...; Ran Nakashima; Shinji Sato; Naoki Kimura; Yuko Kaneko; Takahisa Gono; Stylianos Tomaras; Fabian Nikolai Proft; Marie-Therese Holzer; Margarita Aleksan...; Or Aharonov; Zoltán Griger; Ihsane Hmamouchi; Imane El Bouchti; Zineb Baba; Margherita Giannini; François Maurier; Julien Campagne; Alain Meyer; Daman Langguth; Vidya Limaye; Merrilee Needham; Nilesh Srivastav; Marie Hudson; Océane Landon-Car...; Wilmer Gerardo Ro...; Álvaro Arbeláez; Javier Cajas; José António Pere...; João Eurico Fonseca; Olena Zimba; Doskaliuk Bohdana; Uyi Ima-Edomwonyi; Ibukunoluwa Dedeke; Emorinken Airenakho; Nwankwo Henry Madu; Abubakar Yerima; Hakeem Olaosebikan; Becky A.; Oruma Devi Kousso...; Elisa Palalane; Ho So; Manuel Francisco ...; Lyn Chinchay; José Proaño Bernaola; Victorio Pimentel; Hanan Mohammed Fathi; Reem Hamdy A Moha...; Ghita Harifi; Yurilís Fuentes-S...; Karoll Cabriza; Jonathan Losanto; Nelly Colaman; Antonio Cachafeir...; Generoso Guerra B...; Enrique Julio Gir...; Lilith Stange Nunez; Cristian Vergara; Jossiell Then Báez; Hugo Alonzo; Carlos Benito San...; Rodrigo García Sa...; Alejandro Quiñóne...; Nilmo Chávez; Andrea Bran Ordóñez; Gil Alberto Reyes...; Radames Sierra-Zo...; Dina Arrieta; Eduardo Romero Hi...; Ricardo Saenz; Idania Escalante ...; Wendy Calapaqui; Ivonne Quezada; Gabriela Arredondo; Laura Andreoli; Daniele Lini; Karen Schreiber; Aarat Patel; John D Pauling; Chris Wincup; Bhupen Barman; Erick Adrian Zamo...; Jorge Rojas Serrano; Ignacio García-De...; Iris J Colunga-Pe...; Javier Merayo Cha...; Okwara Celestine ...; Wanruchada Katcha...; Russka Shumnalieva; Leonardo Santos Hoff; Hussein Halabi; Binit Vaidya; A T M Tanveer Hasan; Babur Salim; Tamer Gheita; Tulika Chatterjee
• Keywords: Interquartile range; Depression; Cross-sectional study

Abstract Objectives To investigate health-related quality of life in patients with idiopathic inflammatory myopathies (IIMs) compared those non-IIM autoimmune rheumatic diseases (AIRDs), non-rheumatic (nrAIDs) and without (controls) using Patient-Reported Outcome Measurement Information System (PROMIS) instrument data obtained from the second COVID-19 vaccination disease (COVAD-2) e-survey database. Methods Demographics, diagnosis, comorbidities, activity, treatments PROMIS were analysed. Primary outcomes Global Physical Health (GPH) Mental (GMH) scores. Factors affecting GPH GMH scores IIMs identified multivariable regression analysis. Results We analysed responses 1582 IIM, 4700 AIRD 545 nrAID 3675 controls gathered through 23 May 2022. The median lowest IIM {13 [interquartile range (IQR) 10–15] vs 13 [11–15] AIRDs 15 [13–17] nrAIDs 17 [15–18] controls, P < 0.001}. also significantly lower [13 (IQR 10–15) (13–17) 0.001]. Inclusion body myositis, active glucocorticoid use determinants scores, whereas overlap interstitial lung disease, depression, Function 10a higher Fatigue 4a associated patients. Conclusion Both physical mental health are impaired patients, particularly comorbidities increased fatigue, emphasizing importance patient-reported experiences optimized multidisciplinary care to enhance well-being people IIMs.