Selenium nanoparticles derived from Proteus mirabilis YC801 alleviate oxidative stress and inflammatory response to promote nerve repair in rats with spinal cord injury

• DOI: 10.1093/rb/rbac042
• Publication Date: 2022-06-23T15:35:28Z
• Authors: Xiangyu Liu; Yingji Mao; Shengwei Huang; Weifeng Li; Wei Zhang; Jingzhou An; Yongchao Jin; Jianzhong Guan; Lifang Wu; Pinghui Zhou
• Keywords: Proinflammatory cytokine

Abstract Microbial biotransformation and detoxification of biotoxic selenite into selenium nanoparticles (SeNPs) has emerged as an efficient technique for the utilization selenium. SeNPs are characterized by high bioavailability have several therapeutic effects owing to their antioxidant, anti-inflammatory neuroprotective activities. However, influence on microenvironment disturbances neuroprotection after spinal cord injury (SCI) is yet be elucidated. This study aimed assess SCI explore underlying protective mechanisms. Overall, proliferation differentiation neural stem cells were facilitated derived from Proteus mirabilis YC801 via Wnt/β-catenin signaling pathway. The increased number neurons a greater extent than astrocytes improved nerve regeneration. A dose remarkably protected integrity improve motor function hind limbs decreased expression inflammatory factors such tumor necrosis factor-α interleukin-6 in vivo enhanced production M2-type macrophages regulating polarization, indicating suppressed response. Besides, reversed SCI-mediated reactive oxygen species. In conclusion, treatment holds potential disturbed promote regeneration, representing promising approach SCI.