Effect of intraplaque angiogenesis to atherosclerotic rupture-prone plaque induced by high shear stress in rabbit model

• DOI: 10.1093/rb/rbx007
• Publication Date: 2017-07-07T11:51:13Z
• Authors: Juhui Qiu; Daoxi Lei; Jianjun Hu; Tieying Yin; Kang Zhang; Donghong Yu; Guixue Wang
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Research Articles

Atherosclerotic prone-rupture plaque is mainly localized in the region of entrance to stenosis with high shear stress and reasons are largely unknown. Our hypothesis that such a distribution cells atherosclerotic may depend on angiogenesis. Silastic collars induced regions (20.68 ± 5.27 dynes/cm2) upstream flow low (12.25 1.28 downstream carotid arteries. Compared region, plaques showed more intraplaque haemorrhaging, less collagen higher apoptotic rates vascular smooth muscle cells; endothelial (ECs) were characterized integrity nitric oxide synthase (eNOS) expression (1570.3 345.5% vs 172.9 49.9%). The number microvessels very (15 1.8 n/mm2 3.5 0.4 n/mm2), show ECs abnormal, membrane blebs, intracytoplasmic vacuoles leukocyte infiltration. current study reveals endothelium vulnerability simultaneously regions, we provide evidence for first time maybe responsible rupture-prone formation region.