Global Association Between Cortical Thinning and White Matter Integrity Reduction in Schizophrenia

• DOI: 10.1093/schbul/sbt030
• Publication Date: 2013-03-06T03:48:24Z
• Authors: Akihiko Sasamoto; Jun Miyata; Manabu Kubota; Kazuyuki Hirao; Ryosaku Kawada; Shinsuke Fujimoto; Yusuke Tanaka; Masaaki Hazama; Genichi Sugihara; Nobukatsu Sawamoto; Hidenao Fukuyama; Hidehiko Takahashi; Toshiya Murai
• Keywords: Brain morphometry

Previous neuroimaging studies have revealed that both gray matter (GM) and white (WM) are altered in several morphological aspects schizophrenia patients. Although reported associations between GM WM alterations restricted regions, the existence of a global association pathologies is unknown. Considering wide distribution changes profound genetic background abnormalities, it would be natural to postulate schizophrenia. In this investigation, we studied 35 patients healthy control subjects using T1-weighted magnetic resonance imaging diffusion tensor (DTI) investigated thickness fractional anisotropy (FA) as proxy pathology each tissue. To investigate cortical thickness, surface-based analysis was used. The mean for whole brain computed hemisphere, group comparisons were performed. For DTI data, FA calculated, Subsequently, correlation investigated. Results showed significantly thinner, lower Only patient significant positive correlations hemispheres. This remained even after controlling demographic clinical variables. Thus, our results indicate intertwined at level.