Clinical Characteristics and Frequency of the Hereditary Restless Legs Syndrome in a Population of 300 Patients

• DOI: 10.1093/sleep/23.5.1b
• Publication Date: 2017-02-05T16:13:30Z
• Authors: Juliane Winkelmann; Thomas C. Wetter; Victor Collado-Se...; Thomas Gasser; Martin Dichgans; Alexander Yassour...; Claudia Trenkwalder
• Keywords: Restless Legs Syndrome

There is a genetic contribution to the idiopathic restless legs syndrome (iRLS). An autosomal dominant mode of inheritance suspected, but as yet no gene has been identified. To assess frequency and characteristics hereditary (RLS) in comparison those non-hereditary RLS, we analysed clinical data 300 RLS patients. All patients diagnosed according criteria International Study Group were examined using standard questionnaire covering demographic data, family history, symptoms, subjective sleep disturbances course disease. In all complete neurological examination was performed, selected cases electrophysiological examinations polysomnographic studies. Family history rated definitely positive when at least one first-degree relative classified by authors. If it proved impossible contact members verify reports only having “possible history.” 232 had iRLS 68 secondary due uremia (uRLS). 42.3% with 11.7% uRLS “definite positive” further 12.6% 5.8% RLS. Patients definite significantly younger age onset than negative (35.45 vs. 47.17 years, p< 0.05). The disease similar both groups, except that women experienced worsening symptoms during pregnancy (19.1% 2.6%, Our study shows may experience an earlier Hereditary present similiar signs symptoms.