The Effect of Donepezil on Sleep and REM Sleep EEG in Patients with Alzheimer Disease: A Double-Blind Placebo-Controlled Study

• DOI: 10.1093/sleep/29.2.199
• Publication Date: 2017-02-05T16:49:44Z
• Authors: Walter André dos ...; Dalva Rollemberg ...; Christian Guillem...; Luiz Roberto Ramos; Paulo Henrique Fe...; Sergio Tufik
• Keywords: Sleep

Examine the effects of donepezil on sleep and rapid eye movement (REM) electroencephalogram (EEG) in patients with Alzheimer disease, using polysomnography, correlation between REM EEG parameters cognitive scores.Randomized, double-blind, placebo-controlled design.Two research centers, University Hospital.Thirty-five mild to moderate allocated 2 groups: treated (n=17) placebo (n=18).Patients were administered or placebo.Polysomnography spectral analysis evaluation Disease Assessment Scale, subscale, performed at baseline after 3 6 months. Slowing ratio was slow fast frequency bands. Cognitive data analyzed variance. Correlations improvement also calculated.REM increased significantly months treatment compared (p < .01). Overall theta = .04), frontal .01) delta .03) absolute power during decreased treatment. The occipital slowing .04). overall centroparietal alpha correlated rate subscale (r 0.75, r 0.71, 0.78); p .01).Donepezil enhanced reduced frequencies EEG, suggesting a possible action upon sleep-related cholinergic neurons disease. Furthermore, may predict response donepezil.