Sleep Duration and Cardiometabolic Risk Among Chinese School-aged Children: Do Adipokines Play a Mediating Role?

• DOI: 10.1093/sleep/zsx042
• Publication Date: 2017-03-09T03:44:14Z
• Authors: Lujiao Li; Junling Fu; Xin Ting Yu; Ge Li; Lu Xu; Jinghua Yin; Hong Cheng; Dongqing Hou; Xiaoyuan Zhao; Shan Gao; Wenhui Li; Changhong Li; Struan F. A. Grant; Mingyao Li; Yi Xiao; Jie Mi; Ming Li
• Keywords: Resistin

To assess the associations between sleep duration and cardiometabolic risk factors in Chinese school-aged children to explore possible mediating role of adipokines. Sleep was collected 3166 from Beijing Child Adolescent Metabolic Syndrome study. Glucose homeostasis other were assessed. Serum adipokines including leptin, total high-molecular-weight (HMW) adiponectin, resistin, fibroblast growth factor 21 (FGF21), retinol binding protein 4 (RBP4) determined. Among 6- 12-year-old children, after adjusting for covariates puberty, short associated with increased body mass index (BMI), waist circumference, fasting glucose, insulin model assessment resistance (all p < .0001), higher triglyceride lower high-density lipoprotein cholesterol (p .05), along leptin FGF21 .05) decreased HMW-adiponectin ≤ .01); association remained significant further adjustment BMI. However, these associations, except glucose disappeared adjusted leptin. For 13–18 years old group, BMI, RBP4 but attenuated BMI = .067). Short is strongly obesity hyperglycemia (in 6–12 old), adverse adipokine secretion patterns among children. The appear be more pronounced younger could explained, at least partially, by levels.