Normal reproductive organ development in CF-1 mice following prenatal exposure to bisphenol A

• DOI: 10.1093/toxsci/50.1.36
• Publication Date: 2002-07-26T18:41:00Z
• Authors: S. Z. Cagen; J. M. Waechter; S. S. Dimond; W. J. Breslin; J. H. Butala; F. W. Jekat; R. L. Joiner; R. N. Shiotsuka; G. E. Veenstra; L. R. Harris
• Keywords: Anogenital distance; Reproductive toxicity; Litter

Bisphenol A (BPA) is a monomer used in the manufacture of multitude chemical products, including epoxy resins and polycarbonate. The objective this study was to evaluate effects BPA on male sexual development. This study, performed CF-1 mice, limited measurement sex-organ weights, daily sperm production (DSP), epididymal count, testis histopathology offspring female mice exposed low doses (0, 0.2, 2, 20, or 200 microg/kg/day), by deposition mouth gestation days 11-17. Male development determinations were made at 90 days-of-age. Since conducted investigate clarify low-dose reported S. C. Nagel et al., 1997, Environ. Health Perspect. 105, 70-76, F. vom Saal 1998, Toxicol. Indust. 14, 239-260, our protocol purposely duplicated referenced studies for all factors indicated as critical those investigators. An additional group dosed orally with 0.2 microg/kg/day diethylstilbestrol (DES), which selected based maternal dose have maximum effect prostate developing offspring, (1996, personal communication), al. (1997, Proc. Natl. Acad. Sci. U S 94, 2056-2061). Tocopherol-stripped corn oil vehicle DES, administered alone control animals. No treatment-related clinical observations, body weight, food consumption observed adult females any DES. Similarly, no growth survival from dams treated DES observed. total number pups born per litter slightly lower 200-microg/kg/day when compared controls, but change not considered since size within normal range historical controls. There testes histopathology, production, prostate, preputial gland, seminal vesicle, epididymis weights previously affect these organs an order magnitude higher lower. In conclusion, under conditions 1997 (see above) 1998 above), absence adverse findings challenges "low-dose hypothesis" special susceptibility mammals perinatally ultra-low even potent estrogenic chemicals. Based data present considerable literature similar much doses, should be selective reproductive developmental toxicant.