Developmental immunotoxicity study of tris(chloropropyl) phosphate in Hsd:Sprague Dawley SD rats exposed through dosed feed

• DOI: 10.1093/toxsci/kfaf006
• Publication Date: 2025-02-03T20:23:52Z
• Authors: Victor J Johnson; Kristen Ryan; Michael I Luster; Arun Pandiri; Kristen Hobbie; Michelle Cora; Keith R Shockley; Gary R Burleson; Guanhua Xie; Dori R Germolec
• Keywords: Immunotoxicology; Hematology

Tris(Chloropropyl) phosphate (TCPP) is a member of organophosphate flame retardants (OPFRs) used commonly as replacement for polybrominated diphenyl ethers in consumer and commercial products. Flame have been shown to modulate immune function vivo vitro there evidence that at least some related compounds such pesticides can cause developmental immunotoxicity. Developmental immunotoxicology studies were conducted by administering 0, 2500, 5000 or 10000 ppm TCPP feed pregnant Hsd: Sprague Dawley® SD® rats from gestation day (GD) 6 through weaning on postnatal (PND) 28. Feed exposure was continued the F1 offspring until terminal euthanasia approximately 16-21 weeks age when assessments immunotoxicity conducted. Innate, humoral, cell mediated assessed adults. The antibody forming cells (AFC) response sheep red blood (SRBC) reduced male female treatment group but coincided with bodyweights. AFC also significantly exposed where only moderate effects bodyweights occurred. affected baseline T-cell proliferation without stimulation; however, relevance this change risk unknown. did not affect cytotoxic T-lymphocyte activity. Only minor inconsistent hematology, innate NK function, population distributions spleen observed. Taken together, these data indicate has potential impact humoral responses following exposure.