Testicular Effects Following In Utero Exposure to the Antivirals Acyclovir and Ganciclovir in Rats

• DOI: 10.1093/toxsci/kfu024
• Publication Date: 2014-02-05T01:54:23Z
• Authors: Fabíola Nihi; Davyson Moreira; Ana Carolina Sant...; Caroline Gomes; Samanta Luiza Araujo; Renata Mercer Zaia; Natalia Botelho T...; Leonardo de Athay...; Daniele Dietrich ...; Rosana Nogueira d...; Francisco José Ro...; Anderson Joel Mar...
• Keywords: Male; 0301 basic medicine; 0303 health sciences; Acyclovir; Antiviral Agents; Rats; 3. Good health; 03 medical and health sciences; Maternal Exposure; Pregnancy; Testis; Animals; Female; Ganciclovir

In utero exposure to the antivirals acyclovir and ganciclovir has been reported induce gross structural defects in rat offspring. The present study investigated effects of maternal antiviral treatment on gestation day 10 reproductive nonreproductive organs male offspring with a particular focus testes. Vehicle two doses ganciclovir, 75 300 mg/kg, were administered dams. total fractioned into three subcutaneous applications (3 × distilled water, 3 25 100 mg/kg) that at 8:00 a.m., 1:00 p.m., 6:00 p.m. concentrations measured serum dams 1 h after last administration. Exposure mg/kg induced germ cell deficiency both fetal adult testes, an effect was not seen any other group. Adult rats exposed this high dose exhibited Sertoli cell-only tubules intermingled seminiferous displayed normal size counts, alterations resemble focal syndrome humans. markedly higher than those acyclovir, particularly tested. However, although did deficiency, specific animals, including incomplete eye opening reduced thymus weight.