Is hsa‐miR‐21‐5p a potential biomarker of vulnerable atherosclerotic plaque?

• DOI: 10.1096/fasebj.2019.33.1_supplement.522.3
• Publication Date: 2021-06-22T00:42:54Z
• Authors: Michał Krzysztof ...; Wiktor Paskal; Agata Gondek; Grzegorz Opolski; Agnieszka Barbara...
• Keywords: Unstable angina; Culprit; Vulnerable plaque

INTRODUCTION Vulnerable atherosclerotic plaque localized in coronary arterial bed is clinically important, because its rupture leads to a thrombus generation, which can totally occlude the culprit artery causing myocardial infarction. Therefore finding biomarker characteristic for vulnerable warranted. A potential candidate hsa‐miR‐21‐5p, microRNA particle promotes destabilization by increasing MMP‐9 expression and enhancing local inflammatory state (negative regulation of SMAD‐7 expression). AIM OF THE STUDY Assessment, whether hsa‐miR‐21‐5p serum level differs significantly patients with unstable disease comparing stable MATERIALS AND METHODS Patients (n=42) were divided into 5 groups – ST‐segment elevation infarction (STEMI) (n=8); non‐ST segment (NSTEMI) (n=10), angina (n=8), (sCAD) (n=8) 8 healthy volunteers (W). Serum samples taken relative (in reference hsa‐miR‐191‐5p hsa‐miR‐93‐3p) was measured each sample RT‐qPCR. form STEMI, NSTEMI UA within 24 hours admission, before angiography procedure. The results statistically assessed on STATISTICA 13 programme. RESULTS have shown, that between STEMI group (5,955 vs 2,311; p= 0,04). No significant differences occurred CAD (2,311 1,990; p=0,66) (1,99 1,79; p = 0,77). Comparison other (STEMI NSTEMI, UA) showed no level. CONCLUSIONS study has shown evidence supporting hypothesis, plaque, didn't vary group. However, difference found. This correlation could indicate, plays role initial stages ischemia Support or Funding Information None different UA; CAD; W). image abstract from Experimental Biology 2019 Meeting. There full text article associated this published FASEB Journal .