C‐Reactive Protein Levels and Blood Pressure Loads with Training

• DOI: 10.1096/fasebj.2019.33.1_supplement.692.15
• Publication Date: 2021-06-22T00:52:12Z
• Authors: Adelola O Adeyemo; Michael D. Brown
• Keywords: Aerobic Exercise

Blood pressure (BP) load is the percentage of BP readings above a particular threshold within given period. Elevated loads translate to organ exposures high pressures for greater amounts time. Because this, was heralded as strong predictor target damage (TOD). However, recent evidence has not confirmed its prognostic value 24 hr ambulatory blood monitoring (ABPM). Although questioned, it incorporated in AHA ABPM guidelines children and adolescents. Newer chronic kidney disease untreated hypertensives shown an independent association with various measures TOD. Additionally, marker systemic inflammation (neutrophil‐to‐lymphocyte ratio) been correlate load. Objective This analysis investigated relationship between classic inflammatory biomarker C‐Reactive Protein (CRP) debated measure Load high‐risk population cardiovascular diseases (CVD). Methods Sedentary, middle‐to‐older age African Americans free underwent aerobic exercise training (AEXT) 3x/week weeks. Intensity targets progressed sustain 60% VO 2 max. BMI BP, participants were required maintain constant weight. conducted before after training, determined. Fasted draws utilized at these times circulating CRP categorize future CVD risks based on baseline levels. Slightly less conservative thresholds used because this known population. Results With daytime SBP DBP decreased those only low risk group (p=.047 p=.036, respectively). Nighttime values, however, did change either training. For values final, there no difference (>124 mmHg) classified (<1mg/L), average (1–3mg/L) or (>3mg/L) When more (SBP >139 groups (p<.05). There similar trend (DBP>74 mmHg), appearing differ load, differed when (>119 mmHg, p<.05), but (>104 used. Groups showed difference. Conclusions levels may contribute resultant These be specific indicator response AEXT, especially considered low‐risk. nighttime category, decrease, reasons need further examined. It possible that different stimulus necessary cause changes values. important since clinical events outcomes than adjusted populations. Future studies are needed confirm effect population, inflammation. Support Funding Information NIH Grant #R01 HL085497‐01A1 Systolic (>139 Diastolic (>74 Pressure low‐risk subjects. differences after, training.* p<.05 groups. # image Neither nor (>64 (>119) before, abstract from Experimental Biology 2019 Meeting. full text article associated published The FASEB Journal .