Antifungal and cytotoxic activities of acetone and aqueous extracts of Morinda lucida

• DOI: 10.1096/fasebj.2020.34.s1.03886
• Publication Date: 2020-04-18T03:22:50Z
• Authors: Stephen Olasunkan...; Abimbola Obemisol...; Prudence Ngagule ...; Jacob Nicholas Eloff; Lyndy Joy McGaw
• Keywords: Broth microdilution

Aspergillosis is an opportunistic airborne fungal infection caused by ubiquitous saprophytic moulds of the Aspergillus genus. Infection has been documented in humans and animals, it usually occurs through inhalation unicellular spores known as conidia or, more rarely, after ingestion or wound contamination. Oral candidiasis also important sign for clinical diagnosis indicator evolution immunodeficiency among HIV carriers. Mycotic stomatitis animals Candida spp. most cases. Cryptococcosis a disease man domestic Cryptococcus neoformans complex. In often characterized upper respiratory symptoms, subcutaneous nodules, pneumonia, central nervous system ocular disorders, lymphadenopathy, nodules. Antifungal drugs are unaffordable to rural farmers their efficacy hampered result antimicrobial resistance. Therefore, need seek alternative measures from phytogenic sources urgent. The aim this study was investigate vitro antifungal activity acetone aqueous extracts Morinda lucida (Rubiaceae) against ATCC strains fumigatus , A. flavus albicans well isolates C. using serial microdilution assay. cytotoxicity human colon cancer (Caco‐2) cells total were determined. minimum inhibitory concentration (MIC) both tested organisms ranged 0.11 2.50 mg/ml 0.03 48 72 hours respectively. LC 50 values Caco‐2 0.46 0.58 range selectivity index (SI) 0.23 5.27 19.33 56 2 454 9 000 ml/g potential plant species treatment livestock mycoses supported these results. However, vivo data necessary further claim