Biology of the dopamine transporter on human macrophages

• DOI: 10.1096/fasebj.2021.35.s1.03180
• Publication Date: 2021-06-11T00:33:51Z
• Authors: Phillip Mackie; Adithya Gopinath; Dominic Montas; Alyssa Nielsen; Martin Badov; Joshua Riklan; Basil Hashimi; John McNamee; Rachel Nolan; Kaitlyn Runner; Andria Doty; Adolfo Ramirez‐Za...; Peter Gaskill; Wolfgang Streit; Michael Okun; Habibeh Khoshbouei
• Keywords: 0301 basic medicine; 03 medical and health sciences

Neuromodulators, such as norepinephrine and dopamine, regulate immune responses. In addition to receptor competency, select cells express machinery engage in active neurotransmitter transmission. Specifically, macrophages the (NET) dopamine transporters (DAT). However, how these - classically studied central neurons affect immunity remains poorly understood. To this end, we investigated expression function of NET DAT human macrophages. We found that monocyte-derived functional vitro. A subset intestinal were further confirmed situ. Interestingly, discovered inhibiting DAT, but not NET, enhanced pro-inflammatory macrophage program response an challenge. attribute modulation observed LPS-induced efflux through engages autocrine signaling loop. Collectively, propose actively regulates on cells, and, context, is a novel, dynamic immunomodulator.