Developmental effects of ketamine on inspiratory hypoglossal nerve activity studied in vivo and in vitro

• DOI: 10.1096/fasebj.21.5.a558-c
• Publication Date: 2020-03-20T18:04:28Z
• Authors: Albert Jeffrey Be...; Joy Sebe
• Keywords: Hypoglossal nerve

The effects of ketamine on properties mouse hypoglossal nerve inspiratory bursts (I-bursts) were studied in vivo and vitro. In spontaneously breathing urethane anesthetized mice we observed rhythmic I-phase activity only 1 8 P9 pups. contrast older (≥ P10) was almost always observed. Ketamine caused a reduction I-burst frequency an increase peak integrated all three age groups (P10–P13, P15–P20 adult mice). these synchronous oscillations control after ketamine. Synchronous occur when motoneurons fire clusters action potentials at particular during I-burst. did not change the dominant spectral arising from oscillations. also medullary slice preparation. reduced both amplitude. As studies shift These results demonstrate that vitro significant changes long-time-scale properties, but short-time-scale (synchronous oscillations) are minimal. Supported by NIH grant HL-49657.