Modulatory effect of estradiol on P2X3 receptors expression in dorsal root ganglion of female rats

• DOI: 10.1096/fasebj.21.6.a1272
• Publication Date: 2021-06-21T17:25:49Z
• Authors: bei ma; Ping He; Bing‐Hai Cong; Hong Han; Lu Gao; Li‐Gang Wang; Xin Ni
• Keywords: Dorsal root ganglion

Gonadal hormones have been shown that they may play a role in the perception of painful stimulations. P2X3 receptor has its involvement transduction peripheral pain as well. In this study, we conducted experiments to investigate effects gonadal ovary on expression rat dorsal root ganglion (DRG). The results real time PCR and immunohistochemisty showed higher levels mRNA increased numbers neurons DRG from OVX rats compared with sham-operated rats. Using patch clamp recording, also found isolated cultured neurons, proportion responding transient or biphasic current was raised significantly group Sham-OP group. direct effect estrogen decreased levels, these were reversed by ICI182,780, pure antagonist. Our suggest is tonically inhibited estradiol female Estrogen might participate control through modulating expression.