LIPC and LEPR gene polymorphisms: associations with biochemical parameters and obesity phenotypes in Mexican northwest children from the urban region

• DOI: 10.1096/fasebj.24.1_supplement.546.2
• Publication Date: 2021-06-15T18:35:00Z
• Authors: Javier Magaña‐Gomez; Mayra Arias‐Gastélum; Monica Castro‐Acosta; Joane Hernandez‐M...; Marcela Vergara‐J...
• Keywords: Leptin receptor; Heterozygote advantage

Although the etiology of obesity and comorbidities is poorly understood, genetic factors like polymorphisms strongly influence variations among individuals. Therefore we evaluated role gene encoding hepatic lipase (LIPC) G‐250A leptin receptor (LEPR) Q223R in blood biochemical parameters overweight obese Mexican children. The genotype was determined using PCR‐RFLP analysis for 120 children (60 obese, body mass index (BMI) age gender percentile >85 th 60 lean, 5–85 ). Additionally, were measured. χ 2 analyses applied to test significance differences genotypic frequencies. For both polymorphisms, frequencies prominently different from other populations. All individuals wild‐type homozygote LIPC any showed variant LEPR. No evidence association between LEPR polymorphism BMI observed. However, total cholesterol, VLDL triglycerides significant higher levels (p<0.05) heterozygote (AG) than non‐obese. AG distribution revealed a with impaired lipid metabolism. Further study needed suggest racial polymorphisms. Research supported by CONACyT (Proj. No. 69739).