Zinc status and DNA damage in pediatric patients with acute lymphoblastic leukemia

• DOI: 10.1096/fasebj.24.1_supplement.928.8
• Publication Date: 2021-06-15T18:30:52Z
• Authors: Phanphen Phoonlap...; Samart Pakakasama; Ruchaneekorn W Ka...; Umaporn Suthutvor...; Nalinee Chongviri...
• Keywords: 0301 basic medicine; 03 medical and health sciences; 3. Good health

Zinc is an important element in numerous transcription factors, antioxidant enzymes, and DNA repair proteins. Leukemia is a neoplastic disease that is susceptible to oxidative stress and alteration of essential elements. This study was conducted to determine the status of zinc and DNA damage in pediatric patients with acute lymphoblastic leukemia (ALL).Ten patients, aged 1–12 years, who were newly diagnosed with ALL and 10 age‐matched healthy children (as controls) were recruited in the study. Plasma zinc and 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG) from DNA were evaluated.We found that patients with ALL had lower plasma zinc (9.52 ± 0.64 vs. 13.21 ± 2.11 μmol/mL, p < 0.001), but they had higher levels of 8‐OHdG than controls (2.12 ± 0.37 vs. 0.59 ± 0.15 μg/mL DNA, p < 0.001).In conclusion, pediatric patients with ALL have higher DNA damage but lower levels of zinc than healthy counterparts. The importance of maintaining optimal zinc status in patients may help to reduce DNA damage.This study was funded by The Faculty of Medicine Ramathibodi Hospital Research Grant