The effect of obesity on drug metabolism in African‐American children

• DOI: 10.1096/fasebj.24.1_supplement.967.11
• Publication Date: 2021-06-15T18:33:05Z
• Authors: Manoj Chiney; L'Aurelle Anna Le...
• Keywords: Dextrorphan

It is well established that oxidative enzyme activity differs between obese and healthy weight adults. However, the effect of obesity on drug metabolism in children poorly understood. Therefore this study examined whether vary with respect to phase I activity. In vivo CYP 1A2, 3A 2D6 was assessed African‐American ages 6–10yrs by measuring administered dextromethorphan (0.5mg/kg; max=30 mg) caffeine (11.5mg). Cumulative 8hr metabolic urine ratios (MR) dextromethorphan/dextrorphan dextromethorphan/3‐methoxymorphinan were used determine activity, respectively. Caffeine oral salivary clearance (Dose/AUC 0–8 ) 1A2 Nine 6 evaluated. The median (range) MR 2.08 (0.54–7.36) vs. 9.21 (1.24–19.92) children, 0.0378 (0.0018–0.2144) 0.1839 (0.0077–0.9657) children. Obese trended toward a higher 0.0064 (0.0021–0.0192) L/hr 0.0040 (0.0013–0.0066) L/hr. These preliminary results suggest there may be phenotypic difference 3A, 2D6, Research supported K12HD052187‐01.