Organophosphate pesticide exposure affects zebrafish developmental physiology

• DOI: 10.1096/fasebj.26.1_supplement.674.4
• Publication Date: 2021-06-21T15:39:13Z
• Authors: Hena Garcia; Natalie Hole; Flaka Radoniqi; Hayden Schmidt; Gabriella Orona; Erica A Fradinger
• Keywords: Dichlorvos

Organophosphate pesticides are known to inhibit acetylcholine esterase, an enzyme that degrades at the cholinergic synapse. In this study zebrafish were used understand impact chlorpyrifos, dichlorvos, and diazanon on vertebrate developmental physiology. Pre‐epiboly embryos exposed concentrations ranging from 1μM 1mM. Survival, spontaneous movements, heart rate, swimming behavior, physical abnormalities examined. All three found be toxic developing or above than 100 μM. However, disruption of physiological processes controlled by neurons was only seen in chlorpyrifos dichlorvos. Chlorpyrifos dichlorvos exhibited increased decreased embryonic a transient decrease larval ability. Although most toxic, it had no effect these systems. The effects organophosphate pesticide exposure development diverse may mediated through pathways other inhibition esterase.