Dietary sodium suppresses high‐fat diet weight gain in C57Bl/6J mice

• DOI: 10.1096/fasebj.27.1_supplement.1153.3
• Publication Date: 2021-06-16T10:12:44Z
• Authors: Nicole A. Pearson; Nicole K. Littlejohn; Michael L. Lutter; Justin L. Grobe
• Keywords: Dietary Sodium

To examine the synergistic effects of dietary sodium and fat on weight gain, male C57Bl/6J mice (9 wk) were placed (n=5 each) a 45% (kcal) high‐fat diet (HFD, Bio‐Serv) with 0.25, 0.5, 1, 2, or 4% sodium, standard chow (Teklad 7013). While baseline body masses indistinguishable, rate gain was increased HFD, this reduced increasing content (chow = 0.52±0.02, vs HFD+0.25% 1.88±0.17, HFD+4% 0.70±0.10 g/week). NMR at 4 weeks revealed adipose mass gains that paralleled gains, preventing in dose‐dependent fashion. These maintained confirmed by tissue 10 treatment. Further, it determined made primarily inguinal perigenital fat, no changes interscapular fat. Caloric intake ten treatment similar across groups (11.4 to 15.9 kcal/day), while correlated tightly (0.284 5.942 mEq/day), suggesting regulated food based caloric rather than content. data support hypothesis is positive regulator metabolic rate. Ongoing studies are focused determining whether these mediated suppression circulating renin, new lower (renin‐inducing) USDA guidelines will have unintended consequences.