Dyslipidemia in adult offspring induced by high fat diet rats at perinatal period.

• DOI: 10.1096/fasebj.27.1_supplement.lb751
• Publication Date: 2021-06-21T14:58:59Z
• Authors: Mario Matiotti Neto; Robervan Vidal Sa...; Vitor Ulisses Melo; Fabrício Macedo; José Luiz de Brit...; Márcio Roberto Vi...; Larissa Resende O...; Michael Nadson Sa...; Luciana Catunda B...; João Henrique Cos...; Elizabeth Nasciment; Pauliana Ribeiro ...
• Keywords: Dyslipidemia

Studies have shown that hormonal, metabolic and nutritional disorders during the early phase of development and/or in gestation may lead to transitory or permanent structural functional changes several organs offspring. Our aim was investigate impact high fat diet lactation on biochemical parameters offspring rats. High given from day 1 until weaning puppies. The evaluation performed at 30, 60 90 days after birth Fat Diet dams (HFDD, n= 6) Normal (NDD, 6). Animals HFDD group presented hyperglycemia starting 30 (119 ± 1.6 vs 94.03 2 mg/dl, p<0.05) LDL (45 7 23 4 p<0.05). In OHFD showed difference TAG ( 61 3 51 p<0.05), TC 98 5 75 VLDL 13 0.69 10 0.2 decrease HDL (42 61.42 These findings suggest pregnancy leads dyslipidemia adult Support: CNPq, Fapitec CAPES