Breast milk correlates of immune protection against early infancy Cryptosporidium infection in a rural Tanzanian cohort (1015.6)

• DOI: 10.1096/fasebj.28.1_supplement.1015.6
• Publication Date: 2021-06-16T09:45:38Z
• Authors: Sarah Pedersen; Amanda Wilkinson; Aura Andreasen; Safari Kinung'hi; David Warhurst; Mark Urassa; Denna Mkwashapi; Jim Todd; John Changalucha; Joann McDermid
• Keywords: Cryptosporidium parvum

Breast milk (BM) offers an important immunological bridge from mothers to infants; but BM immunology is incompletely understood. We aimed determine how cytokines and immunoglobulins (Ig) were associated with infant Cryptosporidium infection in a prospective cohort of 108 mother (39% HIV+)/infant pairs. maternal serum was analyzed at month 1, 2, 3, 6 postpartum. Greater IgA, IgM, IgG1, IgG2, IgG3 IgG4 levels consistently lower odds infection, the trend not significant. Absolute cytokine did differ by or HIV uncorrelated. The score determined categorizing (tertiles) calculating individual scores for equation: IFNγ + IL2 IL6 IL13 ‐ TNFα. Infant each time point (OR=0.57; p=0.034), adjusting breastfeeding practice infection. These results suggest are early independent current practices. Grant Funding Source : Supported part National Science Foundation IGERT