Brain ACE2 overexpression stimulates food intake and promotes glucose intolerance in mice (1126.15)

• DOI: 10.1096/fasebj.28.1_supplement.1126.15
• Publication Date: 2021-06-16T09:48:38Z
• Authors: Huijing Xia; Kavaljit Chhabra; Nicole Littlejohn; Nicole Pearson; Justin Grobe; Eric Lazartigues
• Keywords: Glucose Metabolism Disorder; Homeostasis; Carbohydrate Metabolism; Glucose tolerance test

The brain Renin‐Angiotensin System (RAS) plays an important role in the regulation of metabolic function. While ACE2 has been reported to modulate RAS activity, its central metabolism is unknown. To determine metabolism, Body weight and intake behaviors, assessed using cages, were measured 24 wk old non‐transgenic (NT, n=8) transgenic mice overexpressing (SA, n=8). Fasting blood glucose was after a 14 h overnight fasting. Glucose tolerance test performed by measuring at 15, 30, 60 120 min IP injection (2 g/kg). Plasma insulin level ELISA. Interestingly, body significantly higher SA than NT (39±1.5 vs. 31±0.8 g, P <0.05). In addition, exhibited increased daily food (0.12±0.01 0.09±0.01 g/g weight), water (0.14±0.01 0.08±0.01 ml/g fasting (147.8±13 106.5±7 mg/dl), impaired (AUC: 51.6±2 41.5±1.7) plasma (5.5±1.2 1.7±0.3 ng/ml), compared ( These data suggest that involved energy homeostasis. Brain over‐expression leads weight, glycemia intolerance, possibly through stimulating resistance. Grant Funding Source : Supported NIH (NIGMS)