Role of afferent and efferent renal nerves in the antihypertensive effect of renal denervation in Ang II‐salt hypertension (856.4)

• DOI: 10.1096/fasebj.28.1_supplement.856.4
• Publication Date: 2021-06-16T09:56:51Z
• Authors: Jason Foss; Tim Mayerhofer; Laurel Wood; John Collister; John Osborn
• Keywords: Afferent arterioles

Renal denervation (RDNX) attenuates drug resistant hypertension (HT) in humans, but it is unclear whether this due to ablation of afferent or efferent renal nerves. We have previously shown that RDNX the intravenous (IV) AngII‐salt model HT rat. The present study tested hypothesis antihypertensive effect IV nerves, specifically. Male Sprague Dawley rats underwent SHAM surgery, selective nerves by periaxonal capsaicin (renal‐CAP). Rats were instrumented with an catheter for delivery AngII and a radio‐telemeter measure mean arterial pressure (MAP) heart rate (HR). placed on 4% NaCl diet and, after recovery baseline period, was infused (10 ng/kg/min) 16 days. then sacrificed kidneys harvested assayed nerve marker, norepinephrine CGRP. Initial results suggest renal‐CAP similar effects rats. On last day treatment, MAP 161 ± 2.8 mmHg (n = 4) rats, compared 133 11.5 5) 140 5.2 These preliminary support primarily