Low intensity resistance training promotes peripheral and central adjusts on cardiovascular control (881.6)

• DOI: 10.1096/fasebj.28.1_supplement.881.6
• Publication Date: 2021-06-16T09:41:48Z
• Authors: Larissa Oliveira; Fabricio Macedo; Vitor de Melo; Marcelo Mota; Tharciano Luiz da...; Milene Fontes; Michael Nadson Sa...; Robervan dos Santos; Andre Barreto; Márcio Roberto do...; Valter Santana‐Filho
• Keywords: 0303 health sciences; 03 medical and health sciences; 3. Good health

The aim was to evaluate the effects of low intensity resistance training (RT) on blood pressure, cardiovascular autonomic balance and vascular reactivity. One group of animals were submitted to RT. Control animals (CO) were fictitious trained (no exercise). After 8 weeks of RT or fictitious exercise, blood pressure and pulse interval were recorded and mesenteric artery was removed and sliced in rings for vascular reactivity analysis (Acetilcholine (ACh): 10‐9 ‐ 10‐4 M; Nω‐nitro‐L‐arginine methyl ester hydrochloride (L‐NAME): 100µM). The variabilities of pulse interval, blood pressure and spontaneous baroreflex sensitivity (BRS) were analyzed. RT animals showed a reduction in mean arterial pressure (CO 117.04 ± 2.68 vs RT 105.5 ± 4.28), diastolic arterial pressure (CO 107.71 ± 2.95 vs RT 97 ± 3.42) and heart rate (CO 395 ± 7.1 vs RT 344 ± 13.25). In addition, it was seen in trained animals an increase in cardiac vagal modulation (LF/HF: CO 0.35 ± 0.08 vs RT 0.14 ± 0.03), BRS (CO 0.77 ± 0.01 vs RT 1.05 ± 0.1) and percentage of ACh‐induced relaxation of mesenteric arterial rings (pD2: CO 6.2 ± 0.1 vs RT 7.1 ± 0.1) and addition of L‐NAME reduced the ACh‐induced relaxation (CO 52.0 ± 3.2% vs RT 35.8 ± 3.7%). In conclusion, we observed that low intensity RT was able to promote beneficial cardiovascular adaptations mediated by central and peripheral adjustments.Grant Funding Source: Supported by CNPq Foundation (Brazil)