The presence of rs9939609 of FTO and rs17782313 of MC4R may not be associated with obesity, elevated glucose or altered lipid profile in school children of Queretaro: preliminary analysis (LB336)

• DOI: 10.1096/fasebj.28.1_supplement.lb336
• Publication Date: 2021-06-16T09:41:54Z
• Authors: Karla Flores; Olga Garcia; María del Carmen ...; Dolores Ronquillo; Guadalupe Martínez; Jorge Rosado; Juan Solis‐S
• Keywords: 2. Zero hunger; 03 medical and health sciences; 0302 clinical medicine; 3. Good health

The presence of FTO (rs9939609) and MC4R (rs17782313) single‐nucleotide polymorphisms (SNPs) has been associated with an increased risk of overweight and obesity and alterations in the lipids profile. The aim of this study was to investigate the relation between these FTO and MC4R SNPs with the presence of overweight/obesity and metabolic risk in children. A total of 167 school‐aged children (8 ± 1.5 years) from a rural area of 舃舃Queretaro, Mexico, have been evaluated until now. Weight, height, waist circumference and body composition (DXA) were measured. A fasting blood sample was taken for the analysis of glucose and lipid profile. Genotypic frequency of the SNPs was determined using qPCR. Prevalence of obesity and overweight was 12% and 17%, respectively. FTO genotypic frequency for TT, TA and AA was77%, 22% and 1%; the frequency of T and A alleles was 87% and 13%, respectively. As for MC4R, genotypic frequency for TT, TC and CC was 86.3%, 13% and 0.7%; the frequency of T and C alleles was 93% and 7%, respectively. Preliminary results show no relation between the presence of these SNPs and overweight/obesity or with an increased metabolic risk.